Automatic Virtual Crossmatch
PRECISION, SPEED, AND CONFIDENCE IN EVERY COMPATIBILITY DECISION
Faster, More Confident Decisions
A Human Leukocyte Antigen (HLA) Virtual Crossmatch (VxM) assesses the risk of organ rejection by comparing a transplant candidate’s antibodies with a donor’s HLA antigens. This determines whether a recipient has antibodies likely to react against a donor, which is critical for avoiding rejection and ensuring successful transplants.
Buckeye’s Automatic Virtual Crossmatch (VxM), powered by Afflo’s high-resolution data platform, brings automation, accuracy, and integration to this critical process. This will enable faster, more reliable compatibility assessments while easing the manual workload for coordinators and lab staff.
Solving Existing Challenges
Most transplant laboratories still rely on manual processes to perform crossmatches. These workflows create both operational and clinical challenges:
Labor Intensive
Manual interpretation requires specialized expertise and time.
Variability & Risks
Relying on visual comparison can increase variability and introduce a higher risk of human error, leading to slower decision-making.
Data Fragmentation
HLA and antibody data exist across multiple formats and systems, often requiring manual re-entry or data conversion steps.
Limited Throughput
Capacity constraints slow decision-making during time-sensitive cases. Teams face increased stress and administrative workload as a result.
Dynamic Profiles
Candidate antibody data can change and must be continuously updated to remain accurate.
These barriers can delay life-saving decisions and increase the risk of declining viable organs or accepting a higher immunologic risk.
Key Buckeye Solutions and Features
Buckeye’s Automatic Virtual Crossmatch automates the entire compatibility evaluation process. Using advanced algorithms and high-resolution data integration, the system compares donor and recipient profiles in real time, delivering accurate, review-ready match results in seconds.
Key Capabilities
Accepts donor HLA typing at both low- and high-resolution levels
Enables programs to upload candidate antibody files directly without manual re-entry
Automatically compares and processes data to deliver instant, reliable match results
Displays outcomes in an intuitive interface with downloadable reports
Supports rapid review of multiple candidates to increase efficiency and reduce administrative burden
Integrates seamlessly into existing transplant workflows with minimal disruption
By transforming manual review into an automated, standardized workflow, Buckeye helps teams make faster, more confident decisions while reducing late-night workloads and burnout across transplant coordination and lab teams.
Better Results with Fewer Risks
Every minute counts in transplantation. Buckeye’s Automatic Virtual Crossmatch helps programs make confident, timely organ acceptance decisions while reducing clinical and operational risk. When needed, the system can coordinate directly with HLA labs to support confirmatory hard crossmatches, ensuring flexibility for each center’s unique workflow.
With Buckeye VxM, centers can achieve:
Higher accuracy: High-resolution data minimizes false positives and unnecessary declines
Faster turnaround: Real-time results enable quicker organ acceptance decisions
Increased throughput: Handle more offers without increasing staff burden
Better outcomes: Improved matching reduces rejection risk and enhances transplant success
Financial sustainability: Optimized organ utilization and reduced labor demand support long-term program efficiency
Enhanced staff confidence: Tools and insights empower teams to make informed decisions under pressure
Buckeye’s VxM technology aligns with every transplant program’s priorities: speed, safety, and sustainability, while supporting the people who make those outcomes possible.
Match Smarter and Decide Faster
Discover how Buckeye’s Automated Virtual Crossmatch helps you streamline compatibility assessments and strengthen transplant outcomes.